1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Chapter Overview
3.2. 3D Printing Technology
3.2.1. What is 3D Printing?
3.2.2. Historical Evolution
3.3. 3D Bioprinting Process And Components
3.4. Entry of 3D Printing into Medical Arena
3.4.1. Key Players
3.4.2. 3D Bioprinting Applications
3.4.2.1. Toxicity Screening / Drug Testing
3.4.2.2. Tissue Engineering
3.4.2.3. Organ Replacement via Organ Printing
3.4.3. Challenges
3.4.3.1. High Initial Cost
3.4.3.2. Regulatory Issues
3.4.3.3. Functional Aspects Not Yet Fully Tested
3.4.3.4. Limited Capability for Complicated Tissues and Organs
3.4.3.5. Hurts Moral and Religious Beliefs
4. MARKET OVERVIEW
4.1. Chapter Overview
4.2. Limited Professional Bioprinters in Market
4.3. Prices are Largely Prohibitive
4.4. The US is Leading the Efforts; Developing Countries Have Begun to Contribute
4.5. Start-ups Emerging as Key Players
4.6. Bioprinting: Finding its Root in University Research
4.7. Development of Multi-Arm Bioprinters: The Next Generation of Bioprinters
5. PROFILES: COMMERCIAL BIOPRTINERS AND PRODUCTS
5.1. Chapter Overview
5.2. Novogen MMX - Organovo
5.2.1. Overview and Origin
5.2.2. Development of NovoGen MMX
5.2.3. Patents
5.2.4. Awards and Accomplishments
5.2.5. The Bioprinting Process
5.2.6. Bio-ink
5.2.7. Key Features
5.2.8. Applications
5.2.8.1. Microtissues for Drug Discovery and Research
5.2.8.2. Longer Term, Organ Printing for Transplantation
5.2.8.3. Regenerative Medicine
5.2.9. Partnerships and Agreements
5.2.9.1. Pfizer
5.2.9.2. United Therapeutics
5.2.9.3. Autodesk
5.2.9.4. ZenBio
5.2.9.5. OHSU
5.2.9.6. Roche
5.2.9.7. Methuselah Foundation
5.2.9.8. NIH
5.3. 3D-Bioplotter - EnvisionTEC
5.3.1. Overview and Origin
5.3.2. The Bioprinting Process
5.3.3. Applications
5.3.3.1. Provides 'smart' scaffolds for tissue engineering
5.3.3.2. Cell and Tissue Printing
5.3.3.3. 3D-Anatomical Models for Study
5.3.4. Key Features
5.3.5. Academic Institutions using 3D Bioplotter
5.4. BioFactory - regenHU
5.4.1. Overview and Origin
5.4.2. Features
5.4.3. Research Collaborations
5.4.3.1. ETH, Zurich
5.4.3.2. ZHAW
5.4.4. Applications
5.5. BioAssembly Tool - Sciperio / nScrypt
5.5.1. Overview and Origin
5.5.2. The Bioprinting Process
5.5.3. Key Features
5.5.3.1. SmartPump
5.5.4. Collaborations
5.5.4.1. Cardiovascular Innovation Institute
5.5.5. Awards / Accomplishments
5.5.6. Applications
5.5.6.1. Bioficial Heart
5.5.6.2. Other Tissues
5.6. Microfluidic-based Bioprinting Platform - Aspect Biosystems
5.6.1. Overview and Origin
5.6.2. The Bioprinting Process
5.6.3. Key Features
5.6.4. Building Tissue Constructs For Drug Discovery
5.6.5. Awards
5.6.5.1. MEMSCAP Design Award 2013
5.6.5.2. Federal Support Through IRAP
5.7. Modified Ink-jet Bioprinter - TeVido BioDevices
5.7.1. Overview and Origin
5.7.2. Awards/Accomplishments
5.7.3. The Bioprinting Process
5.7.4. Key Features
5.7.5. Applications
5.7.5.1. Breast Reconstruction
5.7.5.2. Drug Testing
5.7.5.3. Other Reconstructive Tissue Products
5.7.5.4. Treatment for Chronic Wounds
5.7.5.5. Breast Augmentation
5.8. Other Initiatives
5.8.1. SkinPrint
5.8.2. 3DDiscovery - regenHU
5.8.2.1. Key Features
5.8.2.2. Research Collaborations
6. PRODUCT PROFILES: ACADEMIC INSTITUTES
6.1. Chapter Overview
6.2. BioPen - University of Wollongong / St. Vincent Hospital
6.2.1. Overview and Origin
6.2.2. The Bioprinting Process
6.2.3. Advantages of BioPen
6.2.4. Applications
6.3. Modified Ink-jet Bioprinter for Skin Cells - Wake Forest Institute for Regenerative Medicine / Armed Forces Institute For Regenerative Medicine
6.3.1. Overview
6.3.2. The Bioprinting Process
6.3.3. Key Features
6.3.4. Bioprinting Human Skin
6.3.5. Awards / Accomplishments
6.4. Modified Ink-jet Printer for Tissues and Organs - Wake Forest Institute for Regenerative Medicine
6.4.1. Overview
6.4.2. The Bioprinting Process
6.4.3. Applications
6.4.3.1. Tissue Patches
6.4.3.2. Potential to Print Organs
6.4.3.3. Organs on a Chip
6.4.4. Awards/Accomplishments
6.5. Regenovo - Hangzhou Dianzi University, China
6.5.1. Overview
6.5.2. The Bioprinting Process
6.5.3. Key Features
6.5.4. Limitations
6.5.5. Applications
6.6. Valve Based Technology - Heriot-Watt University / Roslin Cellab
6.6.1. Overview and Origin
6.6.2. The Bioprinting Process
6.6.3. Key Features
6.6.4. Applications
6.6.4.1. Drug Testing for Pharmaceutical Research
6.6.4.2. Tissue Regeneration
6.6.4.3. Custom-built Replacement Organs
6.6.5. Awards / Accomplishments
6.6.6. Collaborations
6.6.6.1. Reinnervate Ltd.
7. MARKET FORECAST
7.1. Chapter Overview
7.2. Forecast Methodology
7.3. The 3D Bioprinting Market, 2014 - 2030
7.3.1. Background
7.3.2. Market Forecast: Drug Testing (Base Scenario)
7.3.3. Market Forecast: 3D Bioprinted Skin (Base Scenario)
7.3.4. Market Forecast: 3D Printed Cartilage Replacement (Base Scenario)
7.3.5. Market Forecast: 3D Printed Organ Transplants (Base Scenario)
7.3.6. Overall Market Forecast (Base Scenario)
8. SWOT ANALYSIS
8.1. Chapter Overview
8.2. Strengths
8.2.1. Faster Drug Discovery
8.2.2. A Quality Alternative to Animal Testing
8.3. Weaknesses
8.3.1. High Initial Investment
8.3.2. Integration of Vascular Network
8.4. Opportunities
8.4.1. Low Entry Barriers
8.4.2. Growing Wait List for Organ Transplants – A Huge Unmet Need
8.5. Threats
8.5.1. Regulatory Barrier
8.5.2. Commercial 3D Cell Culture Systems
9. CASE STUDIES
9.1. Organovo Holdings, Inc.
9.2. regenHU
10. INTERVIEW TRANSCRIPTS
10.1. Interview 1: n3D Biosciences (Glauco R. Souza, President and CSO & Hubert Tseng, Senior Research Scientist)
10.2. Interview 2: regenHU (Marc Thurner, CEO)
10.3. Interview 3: Sciperio / nScrypt (Kenneth Church, President and CEO & Xudong Chen, Vice President)
10.4. Interview 4: MicroFab Technologies (Anonymous)
10.5. Interview 5: Digilab (Dr. Igor Zlatkin, Application Scientist & Chirantan Kanani, Technology and Product Development)
10.6. Interview 6: TeVido BioDevices (Laura Bosworth, CEO and Co-Founder)
11. CONCLUSION
11.1. 3D Bioprinting has Emerged Well Since Inception
11.2. Commercial Bioprinters Are Limited; Research Labs and Spin-outs from Academia Continue to Progress
11.3. Organ Supply - Demand Gap: A Major Growth Driver
11.4. Overall a Multi-billion Dollar Opportunity by 2030
11.5. Challenges Exist Before Bioprinting Becomes Mainstream
12. APPENDIX 1: LIST OF COMPANIES AND ORGANISATIONS
13. APPENDIX 2: TABLES
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LIST OF FIGURES
Figure 3.1 The 'Bioprinting' Process
Figure 4.1 Industry Sponsored Bioprinters: Regional Distribution
Figure 4.2 Industry Sponsored Bioprinters: Distribution by Status
Figure 4.3 University Sponsored Bioprinters: Regional Distribution
Figure 5.1 Bioplotter: Printing Process
Figure 7.1 Drug Testing Market, Short-Mid Term, Base Scenario (USD MM)
Figure 7.2 Drug Testing Market, Long Term, Base Scenario (USD MM)
Figure 7.3 3D Bioprinted Skin Market, Short-Mid Term, Base Scenario (USD MM)
Figure 7.4 3D Bioprinted Skin Market, Long Term, Base Scenario (USD MM)
Figure 7.5 3D Bioprinted Cartilage Replacement Market, Short-Mid Term, Base Scenario (USD MM)
Figure 7.6 3D Bioprinted Cartilage Replacement Market, Long Term, Base Scenario (USD MM)
Figure 7.7 3D Bioprinted Organ Transplants, Long Term, Base Scenario (USD MM)
Figure 7.8 Overall 3D Bioprinted Products Market, Short-Mid Term, Base Scenario (USD MM)
Figure 7.9 Overall 3D Bioprinted Products Market, Long Term, Base Scenario (USD MM)
Figure 10.1 Process of Magnetic Bioprinting
Figure 10.2 3D Cell Bioprinting: Magnetically Beyond Rings and Dots
Figure 10.3 n3D vs. Organovo 3D Bioprinting
Figure 11.1 3D Bioprinting Market, 2018, 2024, 2030 (USD MM)
Figure 11.2 3D Bioprinting: The Driving Forces
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LIST OF TABLES
Table 3.1 RepRap Project: 3D Printing Machines
Table 3.2 Inputs for 3D Bioprinting
Table 4.1 List of Bioprinters: Industry Sponsored
Table 4.2 Companies Developing Bioprinted Products for Commercial Purposes
Table 4.3 Universities Working in the Area of Bioprinting
Table 5.1 NovoGen MMX: Patent Portfolio
Table 5.2 Materials Used for Scaffolds
Table 5.3 SmartPump - Models and Features
Table 7.1: 3D Bioprinted Applications: Launch Timeline
Table 7.2 3D Bioprinted Skin: Competitive Landscape
Table 8.1 SWOT Analysis
Table 8.2 3D Cell Culture Systems
Table 9.1 3D Liver Assays - Launch Timeline
Table 9.2 Organovo's Plans for Revenue Generation from 3D Bioprinted Liver
Table 9.3 Organovo Revenues – 2011, 2012, and Q1 2013
Table 9.4 regenHU: 3D Bioprinting Product Portfolio
